Super-resolution multimodal spatial transcriptomics reveals an ovoid stem-cell niche structuring de novo shoot regeneration - PubMed
3 days ago
- #plant regeneration
- #stem-cell niche
- #spatial transcriptomics
- Super-resolution spatial transcriptomics maps 1.2 million cells during tomato shoot regeneration, revealing cellular reprogramming stages from wounding to organogenesis.
- A previously unrecognized ovoid stem-cell niche (SCN) structure was identified, consisting of a signaling outer layer, a plastic intermediate compartment, and a quiescent central core.
- EPFL8b signaling pathway is implicated in SCN organization and regeneration, with EPFL8b enriched in the signaling layer and its receptors in the plastic compartment.