Advances on botanicals targeting programmed cell death in acetaminophen-induced liver injury - PubMed
3 days ago
- #Liver Injury
- #Acetaminophen
- #Phytochemicals
- Acetaminophen (APAP) overdose can cause hepatotoxicity, with limited treatment options available.
- N-acetylcysteine (NAC) is the first-line treatment but has a narrow therapeutic window and adverse effects.
- Chinese herbal medicines and their extracts show promise in preventing and treating APAP-induced liver injury (AILI).
- Programmed cell death (PCD) plays a significant role in the pathogenesis of AILI.
- Over 160 studies were reviewed, identifying plant extracts with anti-AILI properties categorized into nine classes.
- Natural compounds like sinomenine, dihydromyricetin, tannic acid, and pterostilbene show potential in modulating PCD pathways.
- Phytochemicals can modulate multiple signaling pathways (Nrf2-HO1, NF-κB, RIPK/MLKL) to alleviate APAP-induced PCD.
- The review provides insights for developing novel hepatoprotective therapeutics.