Efficacy and safety of clopidogrel versus aspirin monotherapy for secondary prevention after percutaneous coronary intervention: a GRADE-assessed meta-analysis with trial sequential analysis - PubMed
4 days ago
- #secondary prevention
- #PCI
- #antiplatelet therapy
- Clopidogrel monotherapy reduces MACCE by 31% compared to aspirin post-PCI with DES.
- No significant difference in major bleeding or all-cause death between clopidogrel and aspirin.
- Clopidogrel significantly lowers stroke and myocardial infarction risks compared to aspirin.
- Meta-analysis includes 5 studies with 16,289 patients, using GRADE and trial sequential analysis.
- Clopidogrel is more effective for long-term secondary prevention without increasing bleeding risks.