Adipocyte-Derived Exosomal miR-5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c-Met/NF-κB Axis to Improve Metabolic Health - PubMed
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- #exosome
- #obesity
- #inflammation
- Adipocyte-derived exosomal miR-5099 mitigates M1 macrophage polarization and adipose inflammation via the c-Met/NF-κB axis.
- Celastrol (CEL) treatment reprograms the miRNA profile of adipocyte-derived exosomes, with miR-5099 being significantly upregulated.
- Exosomal miR-5099 suppresses M1 macrophage polarization, improves metabolic function, and reduces inflammation in obese animals.
- Direct administration of miR-5099 in obese mice ameliorates metabolic disorders, including adipose tissue inflammation and hepatic steatosis.
- miR-5099 enhances systemic insulin sensitivity and glucose homeostasis by targeting the c-Met/NF-κB axis in macrophages.
- miR-5099 offers a therapeutic strategy for obesity and associated comorbidities, circumventing the toxicity of CEL.