Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway - PubMed
4 hours ago
- #insulin
- #cannabinoid receptor 1
- #ERK signaling
- Insulin increases CB1R expression in hepatocytes by activating ERK signaling and inhibiting lysosomal degradation.
- Inhibition of ERK blocks insulin-induced CB1R expression, indicating ERK pathway involvement.
- Insulin suppresses lysosomal degradation of CB1R, stabilizing the receptor and enhancing its effects.
- Hyperinsulinemia exacerbates MASLD/MASH via the insulin-ERK-CB1R axis, suggesting a potential therapeutic target.