An integrative multi-omics approach identifies microbiome alterations linked to pathological and behavioral features in autism spectrum disorder - PubMed
2 days ago
- #multi-omics
- #gut microbiota
- #autism spectrum disorder
- Study uses multi-omics approach to investigate gut-brain axis in 326 children with ASD and 169 TD controls.
- Gut microbial features accurately distinguish ASD from TD children, with Clostridioides difficile being a strong predictor of symptom severity and brain variations.
- Gut and brain differences are age-dependent, diminishing as children with ASD age and converging toward TD patterns.
- Mediation model suggests microbes influence brain structure and behavior via metabolites.
- Findings highlight gut microbiota as a robust predictor of brain and behavioral phenotypes in pediatric ASD, emphasizing need for early, age-stratified therapies.