Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans - PubMed
5 hours ago
- #C. elegans
- #gut-brain axis
- #serotonin signaling
- Intestinal pathogens like P. aeruginosa alter decision-making in fasted C. elegans by modulating central serotonin (5-HT) signaling.
- Fasting activates an intestinal energy-sensing pathway, increasing chemoreceptor SRI-36 in ADF 5-HT neurons, which enhances food attraction despite risks.
- P. aeruginosa infection triggers an immune-brain axis, further amplifying SRI-36 and ADF sensitivity, leading to excessive 5-HT release that suppresses food attraction and prioritizes safety.
- The study reveals a gut-to-brain mechanism where metabolic and immune signals converge on central 5-HT to reshape behavioral strategies.