Estetrol-based combined oral contraceptives: A systematic review of clinical outcomes - PubMed

4 hours ago

Systematic review examines safety and efficacy of estetrol (E4)-containing combined oral contraceptives (COCs) versus traditional COCs.
E4-based COCs show high contraceptive reliability, predictable menstrual cycles, and favorable bleeding patterns.
E4 COCs effectively suppress ovulation with rapid return after discontinuation and have milder effects on coagulation factors, suggesting reduced venous thromboembolism risk.
Study limitations include design biases, small populations, short follow-up, and potential industry sponsorship; further independent research is needed.

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