Distinct predictive factors for acute severe ulcerative colitis in East Asian and Western populations - PubMed
5 hours ago
- #predictive factors
- #acute severe ulcerative colitis
- #East Asia vs Western populations
- This retrospective international study involved 826 acute severe ulcerative colitis (ASUC) patients from East Asia (EA) and Australia/New Zealand (ANZ) to develop predictive models for 1-year colectomy and non-response to corticosteroids, finding distinct predictive factors between these populations.
- In EA patients, predictors of 1-year colectomy included female sex, prior TNF inhibitor exposure, and low albumin, while predictors of non-response included younger age at diagnosis, baseline steroid use, very low albumin, and extraintestinal manifestations.
- EA-derived models performed well in the EA cohort but poorly in ANZ, whereas European models accurately predicted outcomes in ANZ but not in EA, emphasizing the need for population-specific predictive tools.