Lactate metabolism and protein lactylation in cancer - PubMed
6 hours ago
- #cancer-metabolism
- #lactylation
- #immunotherapy
- Lactylation is a post-translational modification linking metabolism to gene regulation in cancer.
- Lactate-derived lactylation affects histone and non-histone proteins, influencing transcription and cellular signaling.
- Lactylation promotes tumor proliferation, metastasis, therapy resistance, and immune evasion by modulating immune cells.
- Regulation involves 'writers' (e.g., p300), 'erasers' (e.g., HDACs, SIRT3), and transporters (e.g., MCT1/4).
- Targeting lactylation enhances immunotherapy (e.g., checkpoint inhibitors, CAR-T) and chemotherapy efficacy.
- Key challenges include specificity, tumor dependency, and lack of clinical biomarkers.
- Future research needs multi-omics approaches to refine therapeutic targets.