Single-nucleus analysis reveals human-specific oligodendrocyte polarization and conserved neuronal responses after severe traumatic brain injury - PubMed
2 hours ago
- #single-nucleus RNA sequencing
- #cross-species comparison
- #traumatic brain injury
- Single-nucleus transcriptomic analysis compares human and mouse cortex after severe traumatic brain injury (sTBI).
- Identifies a human-specific polarized oligodendrocyte state linked to edema progression, absent in mice.
- Highlights ABCA1 and adhesion-related genes in oligodendrocytes, suggesting a role in lipid handling.
- Shows conserved neuronal responses across species but distinct microglial signaling affecting oligodendrocytes.
- Indicates limitations of rodent models in fully capturing human sTBI mechanisms.