Ferroptosis-driven in situ vaccine-like antitumor effects: NIR-triggered IFBM hydrogel synergizes with sorafenib to unleash systemic antitumor immunity - PubMed
5 days ago
- #Photothermal Therapy
- #Immunotherapy
- #Ferroptosis
- Ferroptosis-driven in situ vaccine-like antitumor effects using NIR-triggered IFBM hydrogel combined with sorafenib.
- Engineered ferrous sulfide-bovine serum albumin-cell membrane nanoclusters to induce ferroptosis, co-encapsulated with indocyanine green in a thermosensitive hydrogel.
- Near-infrared-responsive drug release enhances ferroptosis when combined with sorafenib.
- Significant enhancement in dendritic cell-mediated antigen presentation and CD8+ T-cell infiltration observed.
- Complete eradication of distant liver metastases achieved in studies.
- Potential novel cancer treatment strategy by activating systemic antitumor immunity.