Rosa chinensis cv. 'JinBian' flowers alleviates brain damage and cognitive deficit by inhibiting ferroptosis via the Keap1/Nrf2/GPX4 pathway and regulating gut microbiota - PubMed
6 hours ago
- #gut-brain axis
- #neuroprotection
- #ferroptosis
- Rosa chinensis cv. 'JinBian' flowers (RCF) have been used as herbal tea for millennia to prevent aging-related diseases.
- RCF is rich in flavonoids and exhibits strong antioxidant effects, but its specific bioactive compounds and anti-aging mechanisms were unclear.
- The study investigated the neuroprotective mechanisms of RCF extracts, focusing on the ethyl acetate fraction (RE).
- RE showed the highest phenolic and flavonoid content, strongest antioxidant capacities, and significantly reduced ROS in H₂O₂-induced cells.
- UHPLC-ESI-HRMS/MS identified 28 phytochemicals in RE, mainly gallic acid and flavonoid derivatives.
- In D-galactose-induced mice, RE improved memory, reduced anxiety, and activated the Keap1/Nrf2/GPX4 pathway to suppress ferroptosis.
- RE also regulated apoptosis (GSK-3β/Tau/Bcl-2 axis), autophagy (AMPK), and increased beneficial gut bacteria like Lactobacillus and Bifidobacterium.
- The study concludes RE alleviates cognitive deficits by targeting oxidative stress, apoptosis, autophagy, and gut microbiota modulation.