Ventricular enlargement is associated with early Alzheimer's disease pathophysiology - PubMed
3 hours ago
- #Alzheimer's disease
- #CSF clearance
- #ventricular enlargement
- Ventricular enlargement is linked to early Alzheimer's disease (AD) pathophysiology.
- The study examined CSF system abnormalities, including ventricular dilation and choroid plexus volume changes, in relation to brain protein aggregation.
- 378 individuals from the TRIAD cohort were assessed using MRI, amyloid-PET, and tau-PET.
- Larger ventricular and choroid plexus volumes were associated with higher neocortical Aβ-PET SUVR, particularly in the precuneus and cingulate cortices.
- Ventricular volume mediated the effects of ventricular parameters on Aβ load, but not on tau, suggesting distinct clearance mechanisms for these pathologies.
- The findings suggest that changes in ventricular parameters, especially ventricular volume, are associated with upstream AD pathophysiology.