Review of research advances in the cerebral lymphatic system and neurological disorders - PubMed
4 hours ago
- #neurological-disorders
- #glymphatic-system
- #meningeal-lymphatic-vessels
- The central lymphatic system, including the glymphatic system and meningeal lymphatic vessels, plays a crucial role in maintaining central nervous system homeostasis.
- Disruptions in the central lymphatic system can lead to the accumulation of neurotoxic proteins, contributing to neurodegenerative diseases like Alzheimer's and Parkinson's.
- The system also affects cerebrovascular pathology by exacerbating blood-brain barrier disruption and cerebral edema.
- Key factors influencing the cerebral lymphatic system include aquaporin-4 activity, aging, hemodynamics, sleep, and circadian rhythms.
- Targeted modulation of the cerebral lymphatic system shows potential for treating various neurological diseases, though molecular mechanisms remain poorly understood.
- Future research should focus on molecular characterization to identify specific therapeutic targets for clinical translation.