Structured exercise program following adjuvant chemotherapy for colon cancer: A cost-utility analysis of the CHALLENGE trial - PubMed
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- #structured exercise program
- #cost-utility analysis
- #colon cancer
- A structured exercise program (SEP) following adjuvant chemotherapy for colon cancer improves disease-free and overall survival compared to health education materials (HEM).
- The cost-utility analysis from the CHALLENGE trial found that the SEP was dominant over HEM, being less costly and more effective in terms of life-years and quality-adjusted life-years (QALYs).
- The base case analysis from a Canadian public payer perspective showed that the SEP saved $1,589 per participant and added 0.10 QALYs over a 5-year horizon.
- Uncertainty analysis revealed that the SEP was dominant in 53% of bootstrap samples and cost-effective in 80% at a $50,000 per QALY threshold.
- Key cost drivers identified were cancer recurrence or new malignancy and anticancer therapy.
- Scenario analyses, including a 10-year horizon and societal perspective, supported the base case findings, confirming the SEP's cost-effectiveness.