The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells - PubMed
8 hours ago
- #Aurora-A/TPX2 inhibition
- #Breast cancer therapy
- #Small molecule drug discovery
- ATC12 is a new small molecule that inhibits the Aurora-A/TPX2 protein-protein interaction.
- It binds to Aurora-A and competes with TPX2, impairing the complex formation.
- ATC12 reduces cell viability and proliferation in breast cancer 2D cultures, 3D mammospheres, and patient-derived organoids.
- Targeting the Aurora-A/TPX2 complex is proposed as a novel anti-cancer strategy, especially given the limitations of current Aurora-A kinase inhibitors.