A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance - PubMed
4 hours ago
- #regulatory T cells
- #immunomodulator
- #autoimmune therapy
- A peptide immunomodulator (DLST-6P) expands and stabilizes regulatory T cells (Treg cells) for immune tolerance.
- DLST-6P was identified using a deep learning model and shows efficacy in autoimmune and inflammatory disease models.
- The peptide activates MST1, promoting FOXP3 phosphorylation and stabilization, enhancing Treg cell function.
- DLST-6P also alleviates inhibition of IL-2 signaling, sensitizing Treg cells to IL-2 stimulation.
- The study highlights DLST-6P's potential as a peptide-based therapy for immune-related disorders.