Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization - PubMed
6 hours ago
- #oncogene
- #lactylation
- #lung-cancer
- Used Mendelian randomization to identify STMN1 as a lactylation-related driver of lung cancer progression.
- STMN1 upregulation is linked to increased lung cancer risk, shorter survival, and an immunosuppressive tumor microenvironment.
- Knocking down STMN1 inhibited cancer malignancy in vitro and in vivo, while overexpression had opposite effects.
- STMN1 promotes global histone lactylation and H3K18 lactylation, connecting it directly to the lactylation pathway.
- Suggests STMN1 as a novel therapeutic target for lung cancer due to its role in progression and immune suppression.