Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome - PubMed
5 hours ago
- #PCOS
- #apoptosis
- #BPA
- Bisphenol A (BPA) is linked to Polycystic Ovary Syndrome (PCOS) but the molecular mechanisms are unclear.
- The study identified 139 hub genes connecting BPA exposure and PCOS, enriched in hormone metabolism and apoptosis pathways.
- Five key genes (PTAFR, RACGAP1, CYP19A1, FSHR, DMD) were highlighted, showing strong predictive accuracy for PCOS.
- Single-cell RNA-seq analysis in mice revealed cell-type-specific dysregulation of genes like Cyp19a1 and Dmd.
- BPA treatment in vitro regulated hub gene expression, inhibited cell proliferation, and induced apoptosis in granulosa cells.
- The findings suggest BPA disrupts granulosa cell survival in PCOS through apoptosis-related gene regulation.