Evaluation of Women With Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study - PubMed
5 hours ago
- #genetics
- #cardiomyopathy
- #peripartum
- The study compares genetic risk of dilated cardiomyopathy (DCM) in first-degree relatives (FDRs) of women with peripartum cardiomyopathy (PPCM) or DCM.
- Findings show similar DCM/partial DCM risk in FDRs of PPCM and DCM probands, suggesting a shared genetic basis.
- Prevalence of pathogenic or likely pathogenic variants in PPCM probands exceeds population estimates, highlighting the need for genetic evaluations in PPCM patients.
- The study involved 665 FDRs from 452 female probands (67 with PPCM, 385 with DCM), analyzing clinical and genetic data.
- Results indicate that genetic factors play a significant role in PPCM, similar to DCM, challenging previous assumptions about PPCM's distinct etiology.