Mitochondria-associated programmed cell death in pancreatic β cell of T2DM - PubMed
4 hours ago
- #Mitochondria
- #Programmed Cell Death
- #Type 2 Diabetes
- Mitochondria play a key role in pancreatic β-cell dysfunction in type 2 diabetes mellitus (T2DM).
- Programmed cell death (PCD) of β-cells contributes to T2DM progression by impairing insulin secretion and glucose homeostasis.
- Mitochondria coordinate multiple PCD pathways, including apoptosis, necroptosis, ferroptosis, and pyroptosis.
- Structural or functional mitochondrial abnormalities trigger β-cell loss through distinct molecular mechanisms.
- Mitochondria-associated PCD pathways are potential therapeutic targets to preserve β-cell function in T2DM.
- Emerging mitochondrial-targeted strategies aim to attenuate β-cell death and delay T2DM onset and complications.