New insights into synaptic vesicle dysfunction in Parkinson's disease - PubMed
5 hours ago
- #Parkinson's disease
- #synaptic dysfunction
- #neurotransmitter release
- Parkinson's disease (PD) involves synaptic dysfunction before neuronal loss, affecting both motor and non-motor functions.
- Synaptic vesicle (SV) dysfunction is a key pathological mechanism in PD, influenced by PD-linked genes.
- Three critical pathogenic mechanisms identified: impaired neurotransmitter import/storage, disrupted SV pool organization, and altered SV exocytosis/endocytosis.
- Presynaptic pathology in PD leads to postsynaptic plasticity impairments and circuit-level reorganization across brain regions.
- Synaptic vesicle dysfunction is central to PD pathogenesis, offering a promising target for early therapeutic intervention.