Microneedles for the treatment of migraine and orofacial pain: A narrative review - PubMed
5 hours ago
- #migraine
- #microneedles
- #orofacial pain
- Microneedles (MN) technology offers a minimally invasive, localized, or transdermal drug delivery method for migraine and orofacial pain (OFP) conditions.
- Migraine pain can be referred to the orofacial region via trigeminal pathways, overlapping with other OFP conditions.
- The review includes 11 studies, with the most advanced evidence for MN-based interventions in migraine treatment.
- Preclinical studies show MN systems enable rapid drug absorption with bioavailability comparable to subcutaneous injection.
- Clinical studies report high rates of pain relief and symptom freedom in migraine patients using MN-mediated triptan delivery.
- MN technology is also explored for temporomandibular disorders (TMD) and oral mucosal ulcers, showing localized analgesic and anti-inflammatory effects.
- MN-based drug delivery is promising for acute migraine treatment, offering faster absorption and bypassing gastrointestinal limitations.
- Future research should focus on optimizing MN materials and designs for migraine and expanding disease-specific applications.