The SMARCA4-TMEM47 axis plays an essential role in chikungunya virus RNA replication - PubMed
7 hours ago
- #TMEM47
- #CHIKV
- #SMARCA4
- The SMARCA4-TMEM47 axis is crucial for chikungunya virus (CHIKV) RNA replication.
- SMARCA4, a chromatin remodeling factor, regulates the expression of TMEM47, a four-pass transmembrane protein.
- TMEM47 deficiency reduces CHIKV replication in cells and decreases viral loads and pathology in mice.
- TMEM47 interacts with CHIKV RNA and the nonstructural protein nsP1, aiding in viral replication spherule assembly.
- SMARCA4 inhibitors can block CHIKV replication, suggesting potential therapeutic targets.