Microglia heterogeneity and therapeutic strategies in Parkinson's disease - PubMed
6 hours ago
- #Parkinson's disease
- #Neuroinflammation
- #Microglia heterogeneity
- Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neuron loss and α-synuclein aggregation.
- PD features chronic inflammation affecting both the CNS and peripheral organs, with motor and non-motor symptoms.
- Microglia, CNS-resident immune cells, play dual roles in PD: clearing α-syn aggregates but also driving neuroinflammation when overloaded.
- Single-cell transcriptomics has revealed microglia heterogeneity and phenotypic changes in PD, offering new mechanistic insights.
- The review discusses microglial functional, spatial, genetic, and gender-related differences in PD neurodegeneration.
- New therapeutic strategies targeting microglia are summarized, including progress and challenges in preclinical and clinical research.
- The review provides guidance for developing precision therapies modulating microglial function in PD.