National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data - PubMed
5 hours ago
- #mortality trends
- #EHR-based surveillance
- #pediatric sepsis
- Pediatric sepsis causes significant morbidity and mortality in the US.
- The study uses a Pediatric Sepsis Event (PSE) definition adapted from the 2024 Phoenix criteria for EHR-based surveillance.
- Retrospective cohort study analyzed 3.9 million hospitalizations from 2016-2023 across two EHR datasets.
- PSE required presumed infection with concurrent organ dysfunction, with septic shock defined as PSE with cardiovascular dysfunction.
- Sepsis incidence was 1.3% in pediatric hospitalizations, with 10.1% in-hospital mortality.
- PSE definition showed 69.9% sensitivity and 93.1% specificity compared to physician-adjudicated Phoenix sepsis.
- National estimates for 2022 were 18,231 sepsis cases and 1,877 deaths, with no significant trends from 2016-2022.