Small Extracellular Vesicle External Surface Adiponectin-Mediated Adipocytes/Cardiomyocytes Communication in Diabetic Ischemic Heart Failure - PubMed
5 hours ago
- #heart failure
- #diabetes
- #extracellular vesicles
- Small extracellular vesicles (sEVs) from adipocytes (ADps) protect against post-MI cardiac remodeling in nondiabetic mice but not in diabetic hearts.
- Adiponectin (APN) is enriched on the external surface of sEVs and is crucial for their cardioprotective effects.
- Diabetes increases cardiac GRK2 expression and AdipoR1 phosphorylation, disrupting sEV-mediated protection.
- Restoring AdipoR1 function via gene delivery rescues sEV cardioprotection in diabetic mice.
- The study highlights the role of APN on sEVs in adipocyte-cardiomyocyte communication and its disruption in diabetes.