Aging disrupts sympathetic innervation of the thymus - PubMed
6 hours ago
- #sympathetic nervous system
- #neuroimmunology
- #thymic aging
- Aging leads to deterioration of thymic sympathetic innervation, affecting its structure and function.
- Advanced imaging reveals age-related changes in thymic innervation, including axonal degeneration and loss of synapses.
- Sympathectomy impairs thymic homeostasis, while sympathomimetic treatment improves function in aged mice.
- The study challenges previous beliefs about increased thymic innervation with age, highlighting the SNS's role in thymic aging.