Berberine ameliorates estrogen deficiency-associated bone loss via inducing tuft cell expansion - PubMed
5 hours ago
- #Postmenopausal Osteoporosis
- #Gut-Bone Axis
- #Berberine
- Berberine helps reduce bone loss caused by estrogen deficiency by expanding tuft cells in the gut.
- The study used ovariectomy rodent models to show berberine's protective effects on bone resorption.
- Berberine increases intestinal butyrate production, which expands tuft cells via GPR41, improving gut barrier function.
- Tuft cell expansion helps restore gut barrier integrity and corrects the Th17/Treg balance, reducing bone resorption.
- The findings highlight the gut-bone axis's role in estrogen deficiency-related bone loss and berberine's potential as a treatment for postmenopausal osteoporosis.