The DAG/PKC/CREB1/TGF-β1 axis drives shear-wave elastography stiffness and malignant progression in triple-negative breast cancer via lipid metabolic reprogramming - PubMed
5 hours ago
- #Triple-negative breast cancer
- #Lipid metabolism
- #Shear-wave elastography
- Elevated BMI and higher SWE stiffness are linked to poorer prognosis in TNBC patients.
- DAG is identified as a critical lipid molecule promoting SWE stiffness and malignant progression in TNBC.
- The DAG/PKC/CREB1/TGF-β1 axis regulates SWE stiffness and drives TNBC progression via lipid metabolic reprogramming.
- This axis creates a self-sustaining feedback loop that accelerates malignancy by activating cancer-associated fibroblasts.
- SWE stiffness serves as a non-invasive biomarker for predicting prognosis and tailoring therapies in high-risk TNBC patients.