The potential role of synovial T-cell infiltration following knee joint injury in symptoms and progression to osteoarthritis - PubMed
6 hours ago
- #T-cell infiltration
- #synovial inflammation
- #osteoarthritis
- Synovial T-cell infiltration after knee joint injury may influence symptoms and progression to osteoarthritis (OA).
- In mice, increased CD4+ and CD8+ T-cell activation in the synovium was observed post-injury, not seen in monocytes/macrophages, correlating with OA development.
- Patients with meniscal injury and OA showed similar T-cell responses, linking CD8 T-cells to early symptoms and metalloproteinase secretion.
- Temporal imbalances in Th17/Treg and Th1/Th2 lymphocytes were noted during OA initiation and progression.
- Early T-cell depletion in mice provided preliminary evidence that acute T-cell activation may contribute to long-term OA pathology.