An SP110-SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity - PubMed
4 hours ago
- #mitotic fidelity
- #PML bodies
- #SP110-SP100 axis
- The SP110-SP100 axis regulates promyelocytic leukaemia (PML) body dynamics and mitotic fidelity.
- SP110 inhibits type 1 interferon-driven cell death, counteracting the toxic activity of SP100 in PML bodies.
- Loss of SP110 leads to mitotic retention of SP100 and PML bodies, causing chromosome segregation errors, micronucleus formation, DNA damage, and genotoxic cell death.
- Cryo-electron microscopy and AlphaFold modeling show SP110 dissolves toxic SP100 oligomers via direct interactions between their caspase activation and recruitment domains.
- SP100 and SP110 are critical for the disassembly of PML bodies during mitosis; misregulation leads to severe cellular repercussions.