Major clinical improvement in a boy with developmental disabilities and a PTPN4 mutation with intensive re-education and an enriched environment in a day care hospital: a case report - PubMed
4 hours ago
- #PTPN4 gene
- #Neurodevelopmental disorders
- #Enriched environment
- A 7-year-old boy with a PTPN4 gene mutation showed major clinical improvement through intensive re-education and an enriched environment in a day care hospital.
- The PTPN4 gene is involved in glutamate downstream signaling and cerebral maturation, with loss-of-function linked to neurodevelopmental disorders.
- The patient had a severe communication disorder, sensory integration issues, anxiety, and elimination disorder but was not diagnosed with autism spectrum disorder.
- Over 4 years, the boy participated in educational, creative, and academic group activities, which helped generalize new developmental skills and improve social interactions.
- Remarkable progress allowed the patient to attend mainstream school with personalized support, highlighting the benefits of dimensional interventions and enriched environments.