Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study - PubMed
6 hours ago
- #Insulin Resistance
- #MASLD
- #Cardiovascular Disease
- Study investigated insulin resistance (IR) markers and their link to cardiovascular disease (CVD) risk and mortality in MASLD patients using NHANES data (2005–2016).
- Estimated glucose disposal rate (eGDR) showed significant negative correlations with total CVD, CHF, heart attack, and CVD mortality, outperforming other IR surrogates like METS-IR and TyG-BMI.
- eGDR's predictive ability for CVD mortality and risk was robust, improving model performance metrics (C-statistic, NRI, IDI) when added to base models.
- Mediation analysis indicated that liver fibrosis markers partly explained eGDR's association with CVD outcomes, suggesting a pathophysiological link.
- Incorporating eGDR into clinical assessments could enhance early identification and risk stratification of high-risk MASLD individuals for CVD.