IL-17A in the hippocampus regulates despair-like behaviors via inhibitory synaptic transmission - PubMed
5 hours ago
- #depression
- #GABA receptors
- #neuroinflammation
- IL-17A, an inflammatory cytokine, is strongly associated with depression, but its mechanisms in the brain remain unclear.
- IL-17A knockout mice exhibit anti-despair-like behaviors, a key indicator of depression.
- Chronic unpredictable mild stress (CUMS) mice show increased IL-17A levels in the hippocampus.
- IL-17A overexpression in the hippocampus induces despair-like behavior, while its knockout reduces it.
- Enhanced inhibitory synaptic transmission is observed in IL-17A knockout mice.
- GABAA receptor α2 subunit (GABRA2) plays a crucial role in IL-17A's regulation of depressive-like behaviors.
- Reducing GABRA2 expression blocks anti-despair-like behavior in IL-17A knockout mice.
- Overexpression of GABRA2 in the hippocampus alleviates despair-like behavior in CUMS mice.
- The study suggests GABRA2 as a potential therapeutic target for depression.