Targeting Mitochondrial Vulnerabilities in Chronic Myeloid Leukemia: From Pathobiology to Novel Therapeutic Opportunities - PubMed
4 hours ago
- #CML therapeutics
- #mitochondrial dysfunction
- #metabolic reprogramming
- Mitochondria are central to cellular homeostasis, regulating energy, ROS, ion balance, and apoptosis.
- Dysregulation of mitochondrial processes (like fission/fusion) is a cancer hallmark, contributing to metabolic reprogramming and disease progression.
- In CML, mitochondrial abnormalities driven by BCR-ABL1 support proliferation, genomic instability, and apoptosis resistance.
- Mitochondrial adaptations contribute to TKI resistance and leukemic stem cell survival in CML.
- Targeting mitochondrial vulnerabilities (metabolism, redox homeostasis, apoptosis) offers therapeutic opportunities to overcome TKI resistance.