Engineering strategies for the clinical translation of organoids - PubMed
5 hours ago
- #clinical translation
- #organoids
- #tissue engineering
- Organoid clinical translation is reframed as an engineering continuum across in vitro microenvironment, in vitro translational workflows, and in vivo application.
- Engineered microenvironments provide control over stiffness, geometry, and transport to improve reproducibility in organoid construction.
- Engineering enabled workflows introduce dynamic conditioning and functional benchmarking to align in vitro performance with translational requirements.
- For in vivo translation, vascularization and immune compatibility are highlighted as key challenges, with functional integration prioritized over structural persistence.
- The strategies propose a scale-aware, clinically aligned engineering framework to advance organoid translation.