The vagus nerve activated by inflammation co-transmits acute visceral pain via the NTS-PVN pathway - PubMed
6 hours ago
- #Inflammation
- #Visceral Pain
- #Vagus Nerve
- Acute pancreatitis induces visceral pain through inflammation and spinal pathways, but treatment is limited due to insufficient knowledge of nociceptive signal transmission.
- A pancreas-brain axis (pancreas -> NGTRPV1 -> NTSGlu -> PVNGlu) was mapped using viral tracers; AP elevates TNF-α, sensitizing TRPV1+ vagal neurons in the nodose ganglia.
- Bilateral vagotomy and nodose ganglia resiniferatoxin injection partially alleviated AP-induced visceral pain in mice.
- Glutamatergic neurons in the NTS receive signals from activated NGTRPV1 neurons and transmit them to glutamatergic neurons in the PVN.
- Inhibition of the NTSGlu -> PVNGlu pathway via opto- or chemogenetics reduced AP-induced pain behaviors, identifying a vagus nerve-mediated pain co-transmission pathway.