Psychotic Symptoms in Unipolar and Bipolar Depression and Their Impact on Disease Prognosis: A Systematic Review - PubMed
6 hours ago
- #psychotic depression
- #prognosis
- #systematic review
- Psychotic depression (PD) is a severe subtype occurring in both major depressive disorder (MDD) and bipolar disorder (BD).
- PD is associated with greater clinical severity, longer hospitalizations, higher inpatient treatment rates, and lower remission rates compared to non-psychotic depression (NPD).
- PD shows higher risks of relapse, readmission, suicide, and poorer functional outcomes.
- Treatment often involves more frequent use of ECT and pharmacological combinations, though no consistent drug-specific differences were found.
- The review highlights substantial heterogeneity across studies but supports PD as a high-risk subtype requiring intensified assessment and management.