Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment - PubMed
3 months ago
- #immunotherapy
- #neuroscience
- #breast-cancer
- Sensory neurons play a critical role in the immune-excluded tumor microenvironment (TME) of triple-negative breast cancer (TNBC).
- Nerve growth factor (NGF) in TME triggers sensory neurons to secrete calcitonin gene-related peptide (CGRP).
- CGRP activates cancer-associated fibroblasts (CAFs) via RAMP1 receptor, increasing collagen deposition through cAMP/PKA/CREB1 signaling.
- Targeting sensory neurons remodels TME and enhances anti-PD-1 immunotherapy efficacy in TNBC.
- CGRP antagonist rimegepant shows potential as an immuno-sensitizer to improve immunotherapy outcomes.