The mechanism of Tibetan medicine Shibawei Niuhuang Qinggan pills in protecting against acetaminophen-induced acute liver injury in mice by regulating the Keap1-Nrf2 pathway - PubMed
6 hours ago
- #Liver injury
- #Tibetan medicine
- #Oxidative stress
- Shibawei Niuhuang Qinggan pills (SBWNHQGP), a Tibetan medicine, were studied for protection against acetaminophen-induced acute liver injury in mice.
- The study identified 133 chemical components in SBWNHQGP, with 9 verified, and found 86 hepatoprotective components absorbed into circulation and distributed in tissues.
- SBWNHQGP improved liver function, reduced oxidative stress markers, and enhanced liver pathology in mice with acetaminophen-induced injury.
- Mechanistically, SBWNHQGP downregulated Keap1 and p62, while activating the Nrf2 pathway and its antioxidant targets like HO-1 and NQO1.
- Conclusions indicate SBWNHQGP protects against liver injury by boosting antioxidant defenses via the Keap1-Nrf2 pathway, offering a strategy for drug-induced hepatotoxicity.