Complement activation profile in adult primary immune thrombocytopenia - PubMed
6 hours ago
- #clinical biomarkers
- #complement activation
- #primary immune thrombocytopenia
- Complement activation is observed in adult primary immune thrombocytopenia (ITP), with elevated platelet-bound C1q, C3d, and C4d levels in many patients compared to healthy controls.
- Patients with ITP can be classified into three clusters based on complement levels: Cluster 1 (all negative), Cluster 2 (elevated C1q with low C3d/C4d), and Cluster 3 (high C3d and C4d).
- Platelet-associated IgM is mostly found in Cluster 3, while platelet-associated IgG is present in Clusters 2 and 3, indicating differential roles in complement activation.
- Refractory cases to first-line therapy are more common in Clusters 2 and 3, linking complement activation with treatment resistance.
- Complement deposition on platelets correlates with increased immature platelet percentage, suggesting higher platelet turnover in affected patients.
- No significant associations were found between complement activation and PA-GPIIb/IIIa or -GPIb/IX antibodies, C1s plasma ratio, or fatigue scores.