Immune Evasion of Helicobacter pylori and Extra-Gastric Cancer Risk - PubMed
6 hours ago
- #Helicobacter pylori
- #Immune Evasion
- #Extra-gastric Cancer
- H. pylori is a gastric carcinogen with a role in extra-gastric digestive system cancers, including liver, bile duct, colorectal, pancreatic, and esophageal cancers.
- The bacterium evades immunity via virulence factors and persistent colonization, involving exosome communication and gut microbiota dysbiosis through a 'microbiota-epigenetic-cancer regulatory axis'.
- Increased kynurenine production from tryptophan in H. pylori seropositive patients suppresses the immune response by activating the aryl hydrocarbon receptor, promoting tumor growth.