Type 2 diabetes impairs macrophage antimicrobial capability and increases susceptibility to sepsis - PubMed
5 hours ago
- #Sepsis
- #Macrophage dysfunction
- #Type 2 diabetes
- Type 2 diabetes (T2D) increases susceptibility to sepsis by impairing macrophage function.
- Macrophages in T2D show reduced phagocytic and intracellular bacterial killing abilities.
- T2D mice exhibit fewer tissue-resident macrophages and higher bacterial loads in sepsis models.
- Peripheral monocytes from T2D patients and peritoneal macrophages from T2D mice have dampened antimicrobial functions.
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) administration improves survival and reduces bacterial loads in T2D mice by restoring macrophage function.