Simiaoyong'an Decoction Alleviates Atherosclerosis by Inhibiting Adipose Tissue Inflammation Through PPARγ Activation: Integrating Network Pharmacology, Molecular Docking, and Experimental Validation
6 hours ago
- #Atherosclerosis
- #PPARγ activation
- #Traditional Chinese Medicine
- Simiaoyong'an Decoction (SMYA) alleviates atherosclerosis by inhibiting adipose tissue inflammation through PPARγ activation.
- SMYA reduces plaque vulnerability and systemic inflammation (TNF-α and IL-6) in AS model mice and cells.
- SMYA enhances PPARγ expression, increases adiponectin secretion, and inhibits NF-κB, protecting endothelial cells.
- The effects of SMYA are reversed by PPARγ inhibitors, confirming its mechanism of action.
- SMYA is identified as a promising candidate for treating atherosclerosis by suppressing adipose tissue inflammation.