Emerging Insights into the Presentation, Pathophysiology, and Management of Eosinophilic Esophagitis - PubMed
3 days ago
- #EoE
- #Pathophysiology
- #Treatment
- Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease with symptoms like dysphagia and food impaction, varying across populations.
- Pathogenesis includes impaired epithelial barriers, Type 2 inflammation, and eosinophilic infiltration, with recent insights into epithelial alarmins driving inflammation.
- Eosinophil and mast cell depletion does not alleviate symptoms, indicating more complex mechanisms.
- New clinical scoring tools are emerging to enhance diagnosis and disease monitoring.
- Treatment options are expanding, including dietary changes, topical corticosteroids, PPIs, and anti-type 2 biologics like dupilumab for symptom relief.
- Advances in EoE contribute to understanding broader eosinophilic gastrointestinal diseases (EGIDs).