High-Resolution Spatial Multi-Omics Enables Prognostic Scoring in Intrahepatic Cholangiocarcinoma - PubMed
3 days ago
- #intrahepatic cholangiocarcinoma
- #spatial multi-omics
- #prognostic scoring
- Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive liver cancer with poor clinical outcomes.
- The study integrates high-resolution spatial multi-omics technologies, including image mass cytometry (IMC), expansion gel-enabled spatial proteomics, scRNA-seq, bulk proteomics, and multiplex immunofluorescence (mIF).
- A novel spatial multi-modal scoring system was developed using a 155-patient training cohort and validated in an independent 214-patient cohort.
- The approach provides high-dimensional mapping of the tumor microenvironment (TME) at spatial and molecular resolution.
- The scoring system offers potential for risk stratification and guiding therapeutic decisions in iCCA management.