RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions - PubMed
6 hours ago
- #RB protein
- #cohesin regulation
- #chromatin organization
- RB protein, known for repressing E2F activity, also influences chromatin organization by modulating cohesin dynamics at insulators.
- RB colocalizes with cohesin genome-wide and promotes its removal from CTCF sites during mitosis, affecting loop formation and TAD boundary insulation in early G1.
- This role enhances enhancer-promoter interactions marked by H3K27ac, activating hundreds of genes beyond the E2F program, expanding RB's tumor suppressor functions.