Targeting the epithelium in pulmonary fibrosis - PubMed
5 hours ago
- #omic technologies
- #epithelial targeting
- #pulmonary fibrosis
- Idiopathic pulmonary fibrosis (IPF) is characterized by progressive scarring in the distal lung regions.
- Current treatments like nintedanib and pirfenidone target scar-forming fibroblasts but leave unmet medical needs.
- Single-cell sequencing has identified novel disease-associated epithelial populations in IPF.
- Functional co-culture studies highlight the importance of cellular crosstalk in lung homeostasis and disease.
- Advances in 'omic' technologies and spatial profiling are revolutionizing IPF research.
- New functional cell systems and in vivo models are being developed for IPF studies.
- Computational gene set enrichment analysis helps link test systems to clinically relevant biomarkers.
- Epithelial populations identified via cutting-edge technologies may offer new therapeutic targets for IPF.
- Several authors report support and employment from Boehringer Ingelheim, indicating potential conflicts of interest.